The mission of the Nagase R&D Center is to develop a technology platform that backs up the Nagase Group’s future businesses and to act as a driving force in businesses related to life sciences. The Center will continue to energetically offer and provide technological solutions with the aim of strategic involvement with the Group and business expansion based on high-level research and development capabilities

1. Process development technologies

• Develop production methods for unnatural amino acids using Maruoka Catalyst ^® (asymmetric phase-transfer catalyst) and enzymes
• Develop production methods for chiral compounds, such as active pharmaceutical ingredients, intermediates thereof and liquid crystal components, using chiral compounding technologies (hybrid of biotechnology and organic chemistry methods) in elaborate multistep processes

2. Biotechnology (microorganisms, enzymes)

• Identify new enzymes through a ready-to-use microorganism library; explore the possibilities of a ready-to-use microorganism library expanding steadily in its genetic diversity for new enzymes
• Achieve highly effi cient protein production using recombinant microorganisms
• Produce substances using enzymatic reaction technologies
• Develop various chemicals using genetically modifi ed microbes

3. Natural materials development and application technologies

• Identify and evaluate new ingredients for health foods and cosmetics
• Develop formulation methods for health foods and cosmetics

4. Drug discovery support technologies

• Develop multi-color live cell imaging for drug and food evaluation
• Develop reagent kit screening for receptors in humans
• Develop RNAi-related technologies (repression of I:sequence specific gene)

5. Analysis and evaluation technologies

• Analyze imported active pharmaceutical ingredients according to the Japanese Pharmacopeia in compliance with GMP standards and establish specifications

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