Your New Partner for Endotoxin Control
Your New Partner for Endotoxin Control

Developing purification processes to remove endotoxins and obtain low-endotoxin materials consistently is not straightforward.
NAGASE offers endotoxin-removal services for a variety of materials from which low endotoxin levels are a challenge to achieve, or NAGASE can directly provide low-endotoxin materials to you from its catalog.


Biomaterials Proposal

NAGASE has a variety of materials from its product lineup (that may be suitable for your purposes).

Specifications can be customized per your request.

Arcofeliz AL series:Low-Endotoxin Sodium Alginate

Sodium alginate widely studied for medicaldevices and regenerative medicine applications.

Arcofeliz PU-10:Low-Endotoxin Pullulan

Pullulan is characterized by unique properties of high adhesion, sticking force, coating ability, and lubricating performance.

Arcofeliz GE series:Low-Endotoxin Gelatin

Gelatin can be considered to use as a raw material for medical materials.

Arcofeliz EN series:Low-Endotoxin Enzyme

R&D Product.
The lineup includes Alginate lyase and Collagenase.
Both can be considered for use as raw materials for medical materials.

Endotoxin Removal Column

R&D Applications

EOG sterilized and ready to use.

Endotoxin Removal Service

You are welcome to discuss the following issues with NAGASE (ISO 9001 certified):

  • Materialsʼ endotoxin-removal studies.
  • Endotoxin-removal services for a variety of materials from which low endotoxin levels are a challenge to achieve, including commercialization support as needed.

*There may be materials from which endotoxins are difficult to remove; our service welcomes the most challenging of projects.
*“Removal” does not mean that the product’s endotoxin level is 0.


Our low-endotoxin materials and removal services can be used for a variety of applications.


Nagase ChemteX, which is a core manufacturer of the NAGASE group, has developed endotoxin-removal materials utilizing its fine chemical organic synthesis technologies in collaboration with Kumamoto University.

These removal materials have outstanding endotoxin-specific adsorptive capacities, which are effective for removing endotoxins from highly viscous liquids such as biopolymers and scaffolds, where such removal has proven extremely difficult previously.


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Frequently Asked Questions

Since our endotoxin-removal technology targets aqueous solutions, it does not target endotoxins on metals or plastics.

Depending on the type of sample and number of samples, the turnaround time is generally 2 weeks to 1 month.

Since it depends on the sample, quantity, and conditions under consideration, please contact us first.
Also, please let us know if you have a specific budget in mind.

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